She has suicidal thoughts and attempts to assassinate Lady Eboshi of Irontown many times, as San believes that Eboshi's death will result in the end of Irontown and human growth into the surrounding, untouched forest.
San rejects her own humanity and even thinks of herself as a wolf. San's primary concern is protecting the forest and the animals she lives with. Moro raised San as her own daughter, and in turn San treats Moro as her mother and Moro's two natural pups as her siblings. Her parents threw San to her feet and ran away.
When San was a baby, the wolf goddess Moro attacked her parents, who were found damaging the forest.